Interleukin-12 and protective immunity to schistosomes
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چکیده
منابع مشابه
Interleukin-12 and protective immunity to schistosomes.
The attenuated vaccine against Schistosoma mansoni induces Th1-mediated protective immunity and we have sought to identify a role for IL-12 in this model. Elevated levels of IL-12 (p40 mRNA) were detected in the lymph nodes (LN) and the lungs of vaccinated mice, whilst treatment of vaccinated mice with anti-IL-12 antibodies decreased the ratio of IFN gamma:IL-4 secreted by in vitro-cultured LN ...
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متن کاملIn the absence of CD154, administration of interleukin-12 restores Th1 responses but not protective immunity to Schistosoma mansoni.
The cytokine interplay during the development of protective immunity to the radiation-attenuated (RA) schistosome vaccine has been extensively characterized over recent years, yet the role of costimulatory molecules in the development of cell-mediated immunity is much less well understood. Here we demonstrate the importance of CD40/CD154 in vaccine-induced immunity, as CD154(-/-) mice exposed t...
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ژورنال
عنوان ژورنال: Brazilian Journal of Medical and Biological Research
سال: 1998
ISSN: 0100-879X
DOI: 10.1590/s0100-879x1998000100023